Study Uncovers Long-Sought Mechanism That Limits Centriole Duplication, With Implications For Potential Cancer Treatments
Like DNA, centrioles need to duplicate only once per cell cycle. Rogers et al. uncover a long-sought mechanism that limits centriole copying, showing that it depends on the timely demolition of a protein that spurs the organelles' replication. The study appears in the January 26, 2009 issue of the Journal of Cell Biology and online at http://www.jcb.org.
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