Tuesday, September 9, 2008

GlaxoSmithKline's Darapladib Modifies Coronary Plaque Composition And Lowers Lp-PLA2 Activity, A Biomarker Predictive Of Heart Attack Risk

GlaxoSmithKline's Darapladib Modifies Coronary Plaque Composition And Lowers Lp-PLA2 Activity, A Biomarker Predictive Of Heart Attack Risk
GlaxoSmithKline (GSK) announced that results of the Integrated Biomarkers and Imaging Study-2 (IBIS-2) showed that use of the selective Lp-PLA2 (lipoprotein-associated phospholipase A2) inhibitor, darapladib, in addition to standard of care treatment, prevented expansion of the necrotic core, a region within coronary plaque associated with a high risk of rupture.

"Healthy" Individuals May Be At Risk For Heart Disease
In the face of a growing obesity epidemic in the United States, researchers at Wake Forest University Baptist Medical Center have new study results that indicate that how much fat a person has is not as important as where that fat is located when assessing risk for cardiovascular events and metabolic disease. "We are facing an obesity epidemic, which obviously affects many things metabolic abnormalities, cardiovascular disease, etc.," said Jingzhong Ding, M.D.

Endarterectomy Alternative Found In Angioplasty With Stenting
To prevent ipsilateral stroke in patients with symptomatic stenosis of the cartoid artery, cartoid angioplasty with stenting shows a similar level of effectiveness as enarterectomy, according to two articles released on September 6, 2008 in The Lancet Neurology. Stenosis of the lumen of the cartoid artery occurs when the space in the artery is abnormally narrow.

Brush Your Teeth To Reduce The Risk Of Heart Disease
Heart disease is the leading cause of death worldwide. However, many people with cardiovascular disease have none of the common risk factors such as smoking, obesity and high cholesterol. Now, researchers have discovered a new link between gum disease and heart disease that may help find ways to save lives, scientists heard (Tuesday 9 September 2008) at the Society for General Microbiology's Autumn meeting being held this week at Trinity College, Dublin.

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